Biological evaluation of analogues of an insect neuropeptide proctolin.
نویسندگان
چکیده
Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.
منابع مشابه
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ورودعنوان ژورنال:
- Acta biochimica Polonica
دوره 51 1 شماره
صفحات -
تاریخ انتشار 2004